Triglycidyl isocyanurate
CAS No. 2451-62-9
Triglycidyl isocyanurate ( Tris(2,3-epoxypropyl) Isocyanurate; TGI; TGIC; Teroxirone )
产品货号. M27583 CAS No. 2451-62-9
Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
500MG | ¥324 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Triglycidyl isocyanurate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.
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产品描述Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.(In Vitro):Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.(In Vivo):Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice.
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同义词Tris(2,3-epoxypropyl) Isocyanurate; TGI; TGIC; Teroxirone
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通路Apoptosis
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靶点Apoptosis
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2451-62-9
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分子量297.3
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分子式C12H15N3O6
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纯度>98% (HPLC)
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溶解度——
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SMILESO=c1n(CC2CO2)c(=O)n(CC2CO2)c(=O)n1CC1CO1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Guoju Chai, et al. Preparation method of indoline compound, indoline compound and application. CN110452149B
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